Development and validation of spectroscopic simultaneous equation method for simultaneous estimation of Azelnidipine and Valsartan in synthetic mixture

A simple, specific, accurate and precise spectrophotometric method was developed validated for simultaneous estimation of Azelnidipine Valsartan in Synthetic Mixture. The wavelength 240.00 nm 250.00 nm. Beer’s law is obeyed the concentration range 2-10μg/ml 16-80μg/ml correlation coefficient 0.9999 0.9993 respectively. % recovery were found to be 101.2 - 101.9 101.8 Intraday precision 0.06 – 0.24 0.08 0.27 RSD Interday 0.14 0.33 0.11 0.37 proposed also evaluated by Assay mixture containing Valsartan. 100.50 ± 0.002 100.87 0.001 Validation methods carried out according ICH Q2R1Guidelines. reproducible routine analysis both drugs synthetic mixture.